A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods

Takeshi Sugai, Hideaki Kakeya, Hiromichi Ohta

研究成果: Article

34 引用 (Scopus)

抄録

(R)-(-)-Mevalonolactone was synthesized starting from a chiral tertiary α-benzyloxy ester, obtained by the lipase-catalyzed enantioselective hydrolysis of the corresponding racemate, in 7 steps and 21.5% overall yield. Intramolecular Friedel-Crafts reaction of an intermediate worked well as the key-step for the new carbon-carbon bond formation.

元の言語English
ページ(範囲)3463-3468
ページ数6
ジャーナルTetrahedron
46
発行部数10
DOI
出版物ステータスPublished - 1990

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Carbon
Friedel-Crafts reaction
Lipase
Hydrolysis
Esters
mevalonolactone

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

これを引用

A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods. / Sugai, Takeshi; Kakeya, Hideaki; Ohta, Hiromichi.

:: Tetrahedron, 巻 46, 番号 10, 1990, p. 3463-3468.

研究成果: Article

Sugai, Takeshi ; Kakeya, Hideaki ; Ohta, Hiromichi. / A synthesis of (R)-(-)-mevalonolactone by the combination of enzymatic and chemical methods. :: Tetrahedron. 1990 ; 巻 46, 番号 10. pp. 3463-3468.
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