A temporo-spatial regulation of sema3c is essential for interaction of progenitor cells during cardiac outflow tract development

Kazuki Kodo, Shinsuke Shibata, Sachiko Miyagawa-Tomita, Sang Ging Ong, Hiroshi Takahashi, Tsutomu Kume, Hideyuki Okano, Rumiko Matsuoka, Hiroyuki Yamagishi

研究成果: Chapter

抄録

The two cardiac progenitor cell lineages, cardiac neural crest cells (cNCCs) and the second heart field (SHF), play key roles in the development of the cardiac outflow tract (OFT). Both cardiac progenitor cells interact with each other and contribute to OFT formation cooperatively. The neurovascular guiding molecule, semaphorin 3c (Sema3c), is thought to serve as a key attractant for the migration of cNCCs. A previous study reported that Tbx1 null mice showed a significant reduction in Sema3c expression in the OFT region [1]. However, the regulatory effect of Tbx1 on Sema3c was unclear. Here, we show that Sema3c plays key roles in cNCCs-SHF interactions through the regulation by Tbx1 and other molecules during OFT development [2].

本文言語English
ホスト出版物のタイトルMolecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
出版社Springer Singapore
ページ377-379
ページ数3
ISBN(電子版)9789811511851
ISBN(印刷版)9789811511844
DOI
出版ステータスPublished - 2020 1 1

ASJC Scopus subject areas

  • Medicine(all)

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