A transcript map of the candidate genes in the down syndrome critical region of human chromosome 21

Nobuvoshi Shimizu, Nobuaki Shindoh, Hideto Maeda, Akiko Yamakf, Kazuhiko Kawasaki, Shuichi Asakawa, Kazutoyo Osoegawa, Eiichi Soeda, Yoshiko Shimizu, Shinsei Minoshima, Jun Kudoh

研究成果: Article査読

抄録

To isolate genes potentially involved in the pathogenesis of Down syndrome, we have performed exon trapping for the "Down syndrome critical region". We have isolated over 100 exons including those from known human genes and homologs of Drosophila singleminded (sim) and minibrain (mnb) genes. These genes locate in the order of cen-SIM2HCS-TPRD-MNB-KCNJ6-ERG-tel. Drosophila sim and mnb genes are required for development of central nervous system. The structural characteristics of human and mouse SIM2 proteins that contain bHLH and PAS domains and expression in the diencephalon during mouse embryogenesis strongly suggest that SIM proteins function as a transcriptional regulator in the development of the central nervous system. Human MNB cDNA encodes a protein kinase with a nuclear targeting signal and a catalytic domain highly homologous to Drosophila mnb protein kinase and strikingly resembles the rat Dyrk protein kinase with a dual specificity. The MNB mRNA is expressed in various tissues including fetal and adult brains. These results implicate that human MNB protein may play a significant role in a signaling pathway regulating nuclear functions of neuronal cell proliferation, contributing to certain features of Down syndrome.

本文言語English
ページ数1
ジャーナルJapanese Journal of Human Genetics
42
1
出版ステータスPublished - 1997 12 1

ASJC Scopus subject areas

  • 遺伝学(臨床)

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