A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi

Nahoko Uchiyama, Michiho Ito, Fumiyuki Kiuchi, Gisho Honda, Yoshio Takeda, Olimjon K. Khodzhimatov, Ozodbek A. Ashurmetov

研究成果: Article

35 引用 (Scopus)

抜粋

A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.

元の言語English
ページ(範囲)531-533
ページ数3
ジャーナルTetrahedron Letters
45
発行部数3
DOI
出版物ステータスPublished - 2004 1 12
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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  • これを引用

    Uchiyama, N., Ito, M., Kiuchi, F., Honda, G., Takeda, Y., Khodzhimatov, O. K., & Ashurmetov, O. A. (2004). A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi. Tetrahedron Letters, 45(3), 531-533. https://doi.org/10.1016/j.tetlet.2003.10.202