@article{6bd07e9c247149509b14cf5b854a9b36,
title = "A trypanocidal diterpene with novel skeleton from Dracocephalum komarovi",
abstract = "A new diterpene, komarovispirone (1) with a spiro-octahydroindene skeleton, was isolated from Dracocephalum komarovi. The structure was elucidated by extensive analyses of spectral data. Komarovispirone (1) showed trypanocidal activity against epimastigote of Trypanosoma cruzi, the causative agent of American trypanosomiasis, with a minimum lethal concentration of 23μM.",
keywords = "Diterpene, Dracocephalum komarovi, Spiro lactone, Trypanocidal activity, Trypanosoma cruzi",
author = "Nahoko Uchiyama and Michiho Ito and Fumiyuki Kiuchi and Gisho Honda and Yoshio Takeda and Khodzhimatov, {Olimjon K.} and Ashurmetov, {Ozodbek A.}",
note = "Funding Information: This work was supported in part by a Grant-in-Aid for Scientific Research (No. 12576027) from the Japan Society for the Promotion of Science. We are grateful to Dr. N. Kawahara of National Institute of Health Sciences for 600 MHz NMR measurements and to Dr. N. Akimoto of Kyoto University for MS measurements.",
year = "2004",
month = jan,
day = "12",
doi = "10.1016/j.tetlet.2003.10.202",
language = "English",
volume = "45",
pages = "531--533",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "3",
}