A Vinylogous Photocleavage Strategy Allows Direct Photocaging of Backbone Amide Structure

Alicia E. Mangubat-Medina, Samuel C. Martin, Kengo Hanaya, Zachary T. Ball

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Side-chain modifications that respond to external stimuli provide a convenient approach to control macromolecular structure and function. Responsive modification of backbone amide structure represents a direct and powerful alternative to impact folding and function. Here, we describe a new photocaging method using histidine-directed backbone modification to selectively modify peptides and proteins at the amide N-H bond. A new vinylogous photocleavage method allows photorelease of the backbone modification and, with it, restoration of function.

本文言語English
ページ(範囲)8401-8404
ページ数4
ジャーナルJournal of the American Chemical Society
140
27
DOI
出版ステータスPublished - 2018 7 11
外部発表はい

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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