Abatement of morphine-induced slowing in gastrointestinal transit by Dai-kenchu-to, a traditional Japanese herbal medicine

Tomonori Nakamura, Akiko Sakai, Issei Isogami, Kazuhiro Noda, Koichi Ueno, Shingo Yano

研究成果: Article査読

36 被引用数 (Scopus)

抄録

As a way of alleviating severe constipation in cancer patients taking morphine to relieve pain, effects of Dai-kenchu-to (DKT), a traditional Japanese herbal medicine (Kampo medicine), on gastrointestinal transit in mice or on the isolated guinea pig ileum were studied in special reference to morphine. Without altering the anti-nociceptive effect of morphine, DKT was significantly effective against morphine-induced disorder of gastrointestinal transit in mice as assessed by the charcoal meal test for the intestine and measurement of transit time for the colon tract. The results of in vitro studies with guinea pig ileum suggest that abatement of morphine-induced disorder of transit by DKT is caused by both moderate contraction of morphine-treated longitudinal muscle and relaxation of morphine-induced tonic contraction of circular muscle.

本文言語English
ページ(範囲)217-221
ページ数5
ジャーナルJapanese Journal of Pharmacology
88
2
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 薬理学

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