Absolute configuration of (+)-aureothin: A toxic metabolite possessing γ-pyrone unit

Y. Ishibashi, S. Ohba, S. Nishiyama, S. Yamamura

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The absolute configuration of aureothin (1) has been determined by synthesis of (-)-aureonone (4) bearing R-configuration. X-Ray single crystallographic analysis of 21 guaranteed the stereochemistry of the chiral center introduced by Sharpless asymmetric epoxidation, as well as that of isoaureothin (3) which was previously synthesized in a similar pathway. Aureothin (1) itself was also synthesized, although Wittig coupling reaction of 4 under basic conditions, caused a partial epimerization of the chiral center.

本文言語English
ページ(範囲)3643-3649
ページ数7
ジャーナルBulletin of the Chemical Society of Japan
68
12
DOI
出版ステータスPublished - 1995 12 1

ASJC Scopus subject areas

  • 化学 (全般)

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