Acceleration of biodegradation by ultraviolet femtosecond laser irradiation to biodegradable polymer

Akimichi Shibata, Shuhei Yada, Naonari Kondo, Mitsuhiro Terakawa

研究成果: Conference contribution

抄録

Biodegradability is a key property of biodegradable polymers for tissue scaffold applications. Among the methods to control biodegradability, laser processing is a simple technique, which enables the alteration of biodegradability even after molding. Since ultrafast laser processing realizes precise processing of biodegradable polymer with less heat affected zone, ultrafast laser processing has the potential to fabricate tissue scaffolds and to control its biodegradability. In this study, we investigate the effect of femtosecond laser wavelength on the biodegradability of PLGA. We evaluated the biodegradability of PLGA irradiated with femtosecond laser pulses at the wavelength of 800, 400, 266 nm by the measurement of the change in mass of PLGA during water immersion. The results of degradation tests indicate that PLGA irradiated with the shorter wavelength show faster water absorption as well as rapid mass decrease. Since the results of X-ray photoelectron spectroscopy analysis indicate that the chemical bonds of PLGA irradiated with the shorter wavelength are dissociated more significantly, the acceleration of the biodegradation could be attributable to the decrease in molecular weight by chemical bond breaking.

本文言語English
ホスト出版物のタイトルFrontiers in Ultrafast Optics
ホスト出版物のサブタイトルBiomedical, Scientific, and Industrial Applications XVII
編集者Peter R. Herman, Alexander Heisterkamp, Michel Meunier, Roberto Osellame
出版社SPIE
ISBN(電子版)9781510606296
DOI
出版ステータスPublished - 2017
イベントFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017 - San Francisco, United States
継続期間: 2017 1 292017 2 2

出版物シリーズ

名前Proceedings of SPIE - The International Society for Optical Engineering
10094
ISSN(印刷版)0277-786X
ISSN(電子版)1996-756X

Other

OtherFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017
CountryUnited States
CitySan Francisco
Period17/1/2917/2/2

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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