Accuracy of18F-FDG PET/CT in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer

Kazuhiro Kitajima, Koji Murakami, Erena Yamasaki, Ichio Fukasawa, Noriyuki Inaba, Yasushi Kaji, Kazuro Sugimura

研究成果: Article査読

139 被引用数 (Scopus)

抄録

OBJECTIVE. The objective of our study was to evaluate the accuracy of integrated PET and CT (PET/CT) using 18F-FDG in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer, using surgical and histopathologic findings as the reference standard. SUBJECTS AND METHODS. Forty patients with clinical stages IA to IIIC underwent radical hysterectomy, including pelvic lymphadenectomy with or without paraaortic lymphadenectomy, after FDG PET/CT. Lymphadenectomy involved removing all visible lymph nodes in the surgical fields. PET/CT findings were interpreted by two experienced radiologists in consensus and compared with histopathologic results. The criterion for malignancy on PET/CT images was increased radiotracer uptake by a lymph node independent of node size. RESULTS. In total, 62 pathologically positive nodes were found in 10 patients and 60 of 62 dissected metastatic nodes were identified on the CT component. The overall node-based sensitivity, specificity, and accuracy of PET/CT for detecting nodal metastases were 53.3% (32/60), 99.6% (1,419/1,424), and 97.8% (1,451/1,484), respectively. The sensitivity for detecting metastatic lesions 4 mm or less in diameter was 16.7% (4/24), that for lesions between 5 and 9 mm was 66.7% (14/21), and that for lesions 10 mm or larger was 93.3% (14/15). The overall patient-based sensitivity, specificity, and accuracy were 50% (5/10), 86.7% (26/30), and 77.5% (31/40), respectively. CONCLUSION. Integrated FDG PET/CT is superior to conventional imaging techniques, but it is only moderately sensitive in predicting lymph node metastasis preoperatively in patients with endometrial cancer. Even PET/CT should not replace lymphadenectomy.

本文言語English
ページ(範囲)1652-1658
ページ数7
ジャーナルAmerican Journal of Roentgenology
190
6
DOI
出版ステータスPublished - 2008 6月
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

フィンガープリント

「Accuracy of18F-FDG PET/CT in detecting pelvic and paraaortic lymph node metastasis in patients with endometrial cancer」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル