Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten

Katsunori Yamaura, Seri Akiyama, Manabu Oda, Eriko Suwa, Koichi Ueno

研究成果: Letter査読

3 被引用数 (Scopus)

抄録

Acetaminophen (APAP) is one of the most commonly used drugs worldwide to reduce fever, particularly in children. It is generally considered to be a safe drug. However, a number of studies have shown that regular use of APAP increases the risk of developing allergic diseases. Nonetheless, no animal models have been used to investigate these findings. Therefore, we aimed to create an animal model of APAP-induced pruritus in mice. APAP (0.25% and 0.5%) was administered via drinking water daily from infancy, and a suboptimal concentration of 2,4,6-trinitrochlorobenzene (TNCB) was applied repeatedly to each ear three times a week for 7 weeks to evoke chronic allergic contact dermatitis. Neither 0.25% nor 0.5% APAP was overtly hepatotoxic after 73 days of daily administration. Repeated challenge with TNCB evoked increase in the number of scratching bouts compared to day 1. This increase in the number of scratching bouts was significant in 0.25% and 0.5% APAP groups but not in the group treated with TNCB alone. Daily administration of 0.5% APAP significantly increased in the number of scratching bouts compared to TNCB alone on day 29. This animal model will be useful for investigating the mechanism underlying the increased risk of development of eczema caused by regular APAP use and for examining safer and more effective therapy with APAP.

本文言語English
ページ(範囲)669-674
ページ数6
ジャーナルJournal of Toxicological Sciences
36
5
DOI
出版ステータスPublished - 2011
外部発表はい

ASJC Scopus subject areas

  • 毒物学

フィンガープリント

「Acetaminophen enhances pruritus in a mouse model of contact dermatitis induced by suboptimal concentration of hapten」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル