Acoschimperoside P, 2′-acetate: A Hedgehog signaling inhibitory constituent from Vallaris glabra

Yusnita Rifai, Midori A. Arai, Takashi Koyano, Thaworn Kowithayakorn, Masami Ishibashi

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Complete 1H and 13C NMR assignments of acoschimperoside P, 2′-acetate (1) and a new cardiac glycoside (2), isolated from the leaves of Vallaris glabra, are described. Compound 1 was active in the assay for Hedgehog signaling inhibition. In further experiments, this compound showed a strong cytotoxicity against human pancreatic (PANC1) and human prostate (DU145) cancer cells. The expression of GLI-related proteins (PTCH and BCL-2) in a dose-dependent manner was also inhibited by 1.

本文言語English
ページ(範囲)629-632
ページ数4
ジャーナルJournal of Natural Medicines
65
3-4
DOI
出版ステータスPublished - 2011 7月
外部発表はい

ASJC Scopus subject areas

  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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