Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study

Ioan Sporea, Simona Bota, Markus Peck-Radosavljevic, Roxana Sirli, Hironori Tanaka, Hiroko Iijima, Radu Badea, Monica Lupsor, Carmen Fierbinteanu-Braticevici, Ana Petrisor, Hidetsugu Saito, Hirotoshi Ebinuma, Mireen Friedrich-Rust, Christoph Sarrazin, Hirokazu Takahashi, Naofumi Ono, Fabio Piscaglia, Alberto Borghi, Mirko D'Onofrio, Anna GallottiArnulf Ferlitsch, Alina Popescu, Mirela Danila

研究成果: Article査読

136 被引用数 (Scopus)

抄録

Aim: The aim of this international multicenter study was to evaluate the reliability of Acoustic Radiation Force Impulse (ARFI) elastography for predicting fibrosis severity, in patients with chronic hepatitis C. Patients and methods: We compared ARFI to liver biopsy (LB) in 914 patients (10 centers, 5 countries) with chronic hepatitis C. In each patient LB (evaluated according to the METAVIR score) and ARFI measurements were performed (median of 5-10 valid measurements, expressed in meters/second - m/s). In 400 from the 914 patients, transient elastography (TE) was also performed (median of 6-10 valid measurements, expressed in kiloPascals - kPa). Results: Valid ARFI measurements were obtained in 911 (99.6%) of 914 cases. On LB 61 cases (6.7%) had F0, 241 (26.4%) had F1, 202 (22.1%) had F2, 187 (20.4%) had F3, and 223 (24.4%) had F4 fibrosis. A highly significant correlation (r = 0.654) was found between ARFI measurements and fibrosis (p < 0.0001). The predictive values of ARFI for various stages of fibrosis were: F ≥ 1 - cut-off > 1.19 m/s (AUROC = 0.779), F ≥ 2 - cut-off > 1.33 m/s (AUROC = 0.792), F ≥ 3 - cut-off > 1.43 m/s (AUROC = 0.829), F = 4 - cut-off > 1.55 m/s (AUROC = 0.842). The correlation with histological fibrosis was not significantly different for TE in comparison with ARFI elastography: r = 0.728 vs. 0.689, p = 0.28. TE was better than ARFI for predicting the presence of liver cirrhosis (p = 0.01) and fibrosis (F ≥ 1, METAVIR) (p = 0.01). Conclusion: ARFI elastography is a reliable method for predicting fibrosis severity in chronic hepatitis C patients.

本文言語English
ページ(範囲)4112-4118
ページ数7
ジャーナルEuropean Journal of Radiology
81
12
DOI
出版ステータスPublished - 2012 12月
外部発表はい

ASJC Scopus subject areas

  • 放射線学、核医学およびイメージング

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