Acoustic-resolution photoacoustic imaging system with simple fiber illumination

Yasuyuki Tsunoi, Shunichi Sato, Ryota Watanabe, Satoko Kawauchi, Hiroshi Ashida, Mitsuhiro Terakawa

    研究成果: Conference contribution

    4 被引用数 (Scopus)

    抄録

    Acoustic-resolution photoacoustic microscopy (AR-PAM) with dark-field confocal illumination enables unique high-resolution visualization of chromophores in tissue, such as microvasculatures, within depths of a few millimeters. However, most current systems are bulky and use complex optical components for illumination, thus requiring highly sensitive alignment. In this study, we developed a compact alignment-free acoustic-resolution photoacoustic imaging system with simple fiber illumination. Four optical fibers were placed in four directions around a high-frequency (30-MHz) ultrasound sensor attached with the high-numerical-aperture acoustic lens. The setting angle of the fibers were determined to form a dark field on the tissue surface under the acoustic lens and for the four light beams from the fibers to be combined near the focal point of the acoustic lens, i.e., at a depth of around 1.2 mm in the tissue. The acoustic lens and output ends of the fibers were capped with an acoustically and optically transparent engineering plastic sheet, whose surface can be directly placed and scanned on the tissue surface with ultrasound gel. The diameter and height of this imaging head were as small as 32 mm and 27 mm respectively. The phantom study showed that the lateral signal spreading was 120 μm, which agreed well with the theoretical value of 112 μm. With the system, we attempted to image vasculatures in the rat skin, demonstrating high-contrast visualization of the blood vessels of a few hundred micrometers in diameter in the tissue.

    本文言語English
    ホスト出版物のタイトルPhotons Plus Ultrasound
    ホスト出版物のサブタイトルImaging and Sensing 2013
    DOI
    出版ステータスPublished - 2013 5月 28
    イベントPhotons Plus Ultrasound: Imaging and Sensing 2013 - San Francisco, CA, United States
    継続期間: 2013 2月 32013 2月 5

    出版物シリーズ

    名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
    8581
    ISSN(印刷版)1605-7422

    Other

    OtherPhotons Plus Ultrasound: Imaging and Sensing 2013
    国/地域United States
    CitySan Francisco, CA
    Period13/2/313/2/5

    ASJC Scopus subject areas

    • 電子材料、光学材料、および磁性材料
    • 生体材料
    • 原子分子物理学および光学
    • 放射線学、核医学およびイメージング

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