Acquired cystic disease-associated renal cell carcinoma with sarcomatoid change and rhabdoid features

Naoto Kuroda, Masato Tamura, Nobumasa Hamaguchi, Shuji Mikami, Chin Chen Pan, Matteo Brunelli, Guido Martignoni, Ondrej Hes, Michal Michal, Gang Hong Lee

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Acquired cystic disease (ACD)-associated renal cell carcinoma (RCC) is a recently described entity. To the best of our knowledge, there are no reports of ACD-associated RCC with sarcomatoid and rhabdoid changes. In this article, we present the first case of such a tumor. A 56-year-old Japanese man has received long-term hemodialysis and had a history of right renal cancer. Following the discovery of metastatic cancer in the thoracic wall, detailed imaging studies revealed a mass in the left kidney. The histologic examination of the left renal tumor showed ACD-associated RCC with sarcomatoid change and rhabdoid features. Immunohistochemically, intracytoplasmic globular inclusions in rhabdoid cells were positive for vimentin and cytokeratin CAM5.2. The G-band karyotype showed the following changes: 46, X, +X. -Y[1]/43, idem, add(2)(q31), -6, -9, -14, -15, +16, -22, +mar1[6]/46, XY[2]/abnormal cell[11]. In conclusion, pathologists and urologists should be aware that rhabdoid features may occur in ACD-associated RCC and that the loss of chromosomes 9 and 14 may occur during the process of sarcomatoid change in ACD-associated RCC.

本文言語English
ページ(範囲)462-466
ページ数5
ジャーナルAnnals of Diagnostic Pathology
15
6
DOI
出版ステータスPublished - 2011 12月 1

ASJC Scopus subject areas

  • 病理学および法医学

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