@article{7dd9a84ce9884b49875ca0833714824e,
title = "Actinin-4 protein overexpression as a predictive biomarker in adjuvant chemotherapy for resected lung adenocarcinoma",
abstract = "Aim: Although several clinical trials demonstrated the benefits of platinum-combination adjuvant chemotherapy for stage II-IIIA lung adenocarcinoma, predictive biomarkers for the efficacy of such therapy have not yet been identified. We evaluated protein overexpression of actinin-4 as a predictive biomarker of the efficacy of adjuvant chemotherapy in resected lung adenocarcinoma. Materials & methods: We measured actinin-4 protein levels in patients with completely resected stage II-IIIA lung adenocarcinoma using immunohistochemistry and then retrospectively compared survival between adjuvant chemotherapy and observation groups. Results: A total of 148 eligible patients were classified into actinin-4 positive or negative cases by immunohistochemistry. In the former, patients with adjuvant chemotherapy survived significantly longer than those with observation (hazard ratio [HR]: 0.307; p = 0.028). But, no significant survival benefit was noted with adjuvant chemotherapy (HR: 0.926; p = 0.876) in the latter. Conclusion: This marker could predict the efficacy of adjuvant chemotherapy for resected lung adenocarcinoma patients.",
keywords = "actinin-4 (ACTN4), adjuvant chemotherapy, predictive biomarker",
author = "Hideaki Shiraishi and Yutaka Fujiwara and Takanori Kakuya and Koji Tsuta and Noriko Motoi and Nami Miura and Yukio Watabe and Watanabe, {Shun Ichi} and Rintaro Noro and Kengo Nagashima and Wilber Huang and Tesshi Yamada and Hisao Asamura and Yuichiro Ohe and Kazufumi Honda",
note = "Funding Information: This work was supported by the Japan Agency for Medical Research and Development (AMED) Practical Research for Innovation Cancer Control (15ck0106101h0002, K Honda), the AMED Project for Cancer Research And Therapeutic Evolution (P-CREATE) (17cm0106403h0002, K Honda), AMED CREST (17gm0710010h0104 and 17gm0710013h0304, K Honda), a Grant-in Aid for Scientific Research (B) (16H05547), and by the Ministry of Education, Culture, Sports, Science and Technology (METX) of Japan (16K15833, K H.). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2017 Kazufumi Honda.",
year = "2017",
month = sep,
doi = "10.2217/bmm-2017-0150",
language = "English",
volume = "11",
pages = "721--731",
journal = "Biomarkers in Medicine",
issn = "1752-0363",
publisher = "Future Medicine Ltd.",
number = "9",
}