Activation of α7 nicotinic receptors suppresses sucrose addiction in mice

Namiko Kawamura, Ela Novianti, Nobuko Yamada-Goto, Riho Nakama, Akihiro Asakawa, Goro Katsuura, Akio Inui

研究成果: Article査読

抄録

The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse. In this study, we examined the involvement of nicotine receptor subtypes in sucrose addiction in a sucrose preference paradigm. Sucrose preference and intake in mice increased in proportion to stepwise increases in sucrose concentrations. Moreover, sucrose preference and intake following sucrose withdrawal in mice were increased in comparison with the first set of trials. In the present study, α7, but not α4 and β2, nicotinic receptor subunit mRNA was decreased in the nucleus accumbens, but not in the hypothalamus, after sucrose withdrawal and subsequent sucrose intake. Administration of an agonist for α7, but not α4 and β2, nicotinic receptors suppressed the enhancement of sucrose preference and intake following sucrose withdrawal. These findings indicate that α7 nicotinic receptor activation suppresses sucrose addiction in a sucrose preference test in mice.

本文言語English
論文番号110439
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
113
DOI
出版ステータスPublished - 2022 3 8

ASJC Scopus subject areas

  • 薬理学
  • 生物学的精神医学

フィンガープリント

「Activation of α7 nicotinic receptors suppresses sucrose addiction in mice」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル