Activation of a neutrophil-derived inflammatory response in the airways during cardiopulmonary bypass

Toru Kotani, Yoshifumi Kotake, Hiroshi Morisaki, Junzo Takeda, Hideyuki Shimizu, Toshihiko Ueda, Akitoshi Ishizaka

研究成果: Article

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Cardiopulmonary bypass (CPB) is believed to cause postoperative lung dysfunction. To more closely examine the inflammatory processes occurring in the airways during CPB, we serially measured inflammatory mediators, with the assistance of a new bronchoscopic microsample probe, in 11 patients undergoing repair of aortic arch aneurysms. Epithelial lining fluid (ELF) and arterial blood were sampled simultaneously after induction of anesthesia, at the time of pulmonary reperfusion, and at the end of surgery. A decrease in the Pao2/Fio2 ratio was observed at the end of surgery (P = 0.029). Although the ELF concentrations of interleukin (IL)-8, IL-6, and neutrophil elastase had increased significantly at the end of surgery (median = 23,200, 1818, and 12,900 μg/mL, respectively), they did not correlate with the degree of hypoxemia. Neutrophil elastase increased significantly at the time of pulmonary reperfusion, before IL-8 and IL-6, and independently of blood transfusions. At the end of surgery, IL-6 in ELF correlated with total blood transfusion volume (ρ = 0.731, P = 0.011). These results indicate that a neutrophil-derived inflammatory response is activated in the airway in the early phase of CPB.

元の言語English
ページ(範囲)1394-1399
ページ数6
ジャーナルAnesthesia and analgesia
103
発行部数6
DOI
出版物ステータスPublished - 2006 12 1

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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