Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra

Mizue Ohsugi, Wenzhe Fan, Koji Hase, Quanbo Xiong, Yasuhiro Tezuka, Katsuko Komatsu, Tsuneo Namba, Tomohiro Saitoh, Kenji Tazawa, Shigetoshi Kadota

研究成果: Article査読

140 被引用数 (Scopus)

抄録

The active-oxygen scavenging activity of 70 traditional herbal medicines used in China and Japan as nourishing tonics were evaluated by electron spin resonance (ESR) technique, in order to evaluate their effectiveness for anti-aging and to search for new active-oxygen scavengers from natural resources. Most of the 70 herbal medicines showed scavenging activity with various intensities. Areca catechu (methanol extract), Dendrobium plicatile (methanol extract), Juglans regia (water extract), Paeonia lactiflora (methanol extract), Psychotria serpens (water and methanol extracts), Rhodiola sacra (water and methanol extracts) and Uncaria rhynchophylla (water extract) especially showed strong scavenging activity against superoxide anion radical (.O2-), while J. regia (water and methanol extracts), Morus alba (water extract) and Schisandra chinensis (water extract) revealed strong scavenging activity against hydroxyl radical (HO.). In addition, the active-oxygen scavenging activities of 19 compounds isolated from R. sacra were also examined, and hydroquinone (1), caffeic acid (3), protocatechuic acid (6), gallic acid (7), (-)-epigallocatechin 3-O-gallate (8), 3-O-galloylepigallocatechin-(4β→8)-epigallocatechin 3-O-gallate (10), heterodendrin (17) and gallic acid 4-O-β-D-glucopyranoside (19) were found to show mild or strong inhibitory activity against superoxide anion radical (.O2-), while 4-hydroxybenzoic acid (2), 3, 4-hydroxycinnamic acid (4), 6-8 and 19 inhibited hydroxyl radical (OH.). These active-oxygen scavengers may contribute, to different extents, to their anti-aging action. Copyright (C) 1999 Elsevier Science Ireland Ltd.

本文言語English
ページ(範囲)111-119
ページ数9
ジャーナルJournal of Ethnopharmacology
67
1
DOI
出版ステータスPublished - 1999 10月 1
外部発表はい

ASJC Scopus subject areas

  • 薬理学
  • 創薬

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