Acute and subacute inhalation toxicity of diborane in male ICR mice

Takamoto Uemura, Kazuyuki Omae, Hiroshi Nakashima, Haruhiko Sakurai, Kazuto Yamazaki, Toshikatsu Shibata, Koji Mori, Mitsuhiro Kudo, Hirokazu Kanoh, Masatomo Tati

研究成果: Article

8 引用 (Scopus)

抄録

To clarify the toxicity of diborane, we conducted acute (15 ppm for 1, 2, 4 or 8h) and subacute (5 ppm for 2 or 4 weeks) inhalation studies on ICR mice. The concentration resulting in a 50% kill after 4 h exposure was 31.5 ppm. body weight gain was suppressed and the lung weight was increased in diborane-exposed mice in both acute and subacute studies. In the acute study, diffuse pan bronchiolitis-like lesions developed in the lung in various degrees depending on exposure time, which can be pathologically characterized as infiltration of inflammatory cells into the terminal bronchioles and surrounding alveoli, pulmonary congestion and bleeding and/or edema. In the subacute study, we observed lymphoid hyperplasia in the perivascular and peribronchial areas, and infiltration of macrophage and plasma cells into the alveoli. In the mice exposed for 4 weeks, the lesions were more severe than in those exposed for 2 weeks, consisting of hyperplasia and desquamation of Clara cells. In the nasal cavity, we saw mucous exudate and inflammatory cells, suggesting irritation caused by diborane. The histopathological findings, except for the respiratory organs, did not reveal any exposure-related changes. No significant changes were seen in hematological and serum biochemical examinations either. In conclusion, the target organ of diborane inhalation is the respiratory organs, particularly the lung. Further inhalation experiments are essential to investigate the safety exposure levels of diborane.

元の言語English
ページ(範囲)397-404
ページ数8
ジャーナルArchives of Toxicology
69
発行部数6
DOI
出版物ステータスPublished - 1995 5

Fingerprint

Inbred ICR Mouse
Inhalation
Toxicity
Infiltration
Lung
Hyperplasia
Pulmonary Alveoli
Bronchioles
Bronchiolitis
Macrophages
Nasal Cavity
Exudates and Transudates
Plasma Cells
Weight Gain
Edema
Body Weight
diborane
Hemorrhage
Plasmas
Safety

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

これを引用

Uemura, T., Omae, K., Nakashima, H., Sakurai, H., Yamazaki, K., Shibata, T., ... Tati, M. (1995). Acute and subacute inhalation toxicity of diborane in male ICR mice. Archives of Toxicology, 69(6), 397-404. https://doi.org/10.1007/s002040050190

Acute and subacute inhalation toxicity of diborane in male ICR mice. / Uemura, Takamoto; Omae, Kazuyuki; Nakashima, Hiroshi; Sakurai, Haruhiko; Yamazaki, Kazuto; Shibata, Toshikatsu; Mori, Koji; Kudo, Mitsuhiro; Kanoh, Hirokazu; Tati, Masatomo.

:: Archives of Toxicology, 巻 69, 番号 6, 05.1995, p. 397-404.

研究成果: Article

Uemura, T, Omae, K, Nakashima, H, Sakurai, H, Yamazaki, K, Shibata, T, Mori, K, Kudo, M, Kanoh, H & Tati, M 1995, 'Acute and subacute inhalation toxicity of diborane in male ICR mice', Archives of Toxicology, 巻. 69, 番号 6, pp. 397-404. https://doi.org/10.1007/s002040050190
Uemura T, Omae K, Nakashima H, Sakurai H, Yamazaki K, Shibata T その他. Acute and subacute inhalation toxicity of diborane in male ICR mice. Archives of Toxicology. 1995 5;69(6):397-404. https://doi.org/10.1007/s002040050190
Uemura, Takamoto ; Omae, Kazuyuki ; Nakashima, Hiroshi ; Sakurai, Haruhiko ; Yamazaki, Kazuto ; Shibata, Toshikatsu ; Mori, Koji ; Kudo, Mitsuhiro ; Kanoh, Hirokazu ; Tati, Masatomo. / Acute and subacute inhalation toxicity of diborane in male ICR mice. :: Archives of Toxicology. 1995 ; 巻 69, 番号 6. pp. 397-404.
@article{8c01abba1d9b4e73a9b7437fd6a93a1d,
title = "Acute and subacute inhalation toxicity of diborane in male ICR mice",
abstract = "To clarify the toxicity of diborane, we conducted acute (15 ppm for 1, 2, 4 or 8h) and subacute (5 ppm for 2 or 4 weeks) inhalation studies on ICR mice. The concentration resulting in a 50{\%} kill after 4 h exposure was 31.5 ppm. body weight gain was suppressed and the lung weight was increased in diborane-exposed mice in both acute and subacute studies. In the acute study, diffuse pan bronchiolitis-like lesions developed in the lung in various degrees depending on exposure time, which can be pathologically characterized as infiltration of inflammatory cells into the terminal bronchioles and surrounding alveoli, pulmonary congestion and bleeding and/or edema. In the subacute study, we observed lymphoid hyperplasia in the perivascular and peribronchial areas, and infiltration of macrophage and plasma cells into the alveoli. In the mice exposed for 4 weeks, the lesions were more severe than in those exposed for 2 weeks, consisting of hyperplasia and desquamation of Clara cells. In the nasal cavity, we saw mucous exudate and inflammatory cells, suggesting irritation caused by diborane. The histopathological findings, except for the respiratory organs, did not reveal any exposure-related changes. No significant changes were seen in hematological and serum biochemical examinations either. In conclusion, the target organ of diborane inhalation is the respiratory organs, particularly the lung. Further inhalation experiments are essential to investigate the safety exposure levels of diborane.",
keywords = "Diborane, Inhalation, Mice, Toxicity",
author = "Takamoto Uemura and Kazuyuki Omae and Hiroshi Nakashima and Haruhiko Sakurai and Kazuto Yamazaki and Toshikatsu Shibata and Koji Mori and Mitsuhiro Kudo and Hirokazu Kanoh and Masatomo Tati",
year = "1995",
month = "5",
doi = "10.1007/s002040050190",
language = "English",
volume = "69",
pages = "397--404",
journal = "Archiv fur Toxikologie",
issn = "0003-9446",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Acute and subacute inhalation toxicity of diborane in male ICR mice

AU - Uemura, Takamoto

AU - Omae, Kazuyuki

AU - Nakashima, Hiroshi

AU - Sakurai, Haruhiko

AU - Yamazaki, Kazuto

AU - Shibata, Toshikatsu

AU - Mori, Koji

AU - Kudo, Mitsuhiro

AU - Kanoh, Hirokazu

AU - Tati, Masatomo

PY - 1995/5

Y1 - 1995/5

N2 - To clarify the toxicity of diborane, we conducted acute (15 ppm for 1, 2, 4 or 8h) and subacute (5 ppm for 2 or 4 weeks) inhalation studies on ICR mice. The concentration resulting in a 50% kill after 4 h exposure was 31.5 ppm. body weight gain was suppressed and the lung weight was increased in diborane-exposed mice in both acute and subacute studies. In the acute study, diffuse pan bronchiolitis-like lesions developed in the lung in various degrees depending on exposure time, which can be pathologically characterized as infiltration of inflammatory cells into the terminal bronchioles and surrounding alveoli, pulmonary congestion and bleeding and/or edema. In the subacute study, we observed lymphoid hyperplasia in the perivascular and peribronchial areas, and infiltration of macrophage and plasma cells into the alveoli. In the mice exposed for 4 weeks, the lesions were more severe than in those exposed for 2 weeks, consisting of hyperplasia and desquamation of Clara cells. In the nasal cavity, we saw mucous exudate and inflammatory cells, suggesting irritation caused by diborane. The histopathological findings, except for the respiratory organs, did not reveal any exposure-related changes. No significant changes were seen in hematological and serum biochemical examinations either. In conclusion, the target organ of diborane inhalation is the respiratory organs, particularly the lung. Further inhalation experiments are essential to investigate the safety exposure levels of diborane.

AB - To clarify the toxicity of diborane, we conducted acute (15 ppm for 1, 2, 4 or 8h) and subacute (5 ppm for 2 or 4 weeks) inhalation studies on ICR mice. The concentration resulting in a 50% kill after 4 h exposure was 31.5 ppm. body weight gain was suppressed and the lung weight was increased in diborane-exposed mice in both acute and subacute studies. In the acute study, diffuse pan bronchiolitis-like lesions developed in the lung in various degrees depending on exposure time, which can be pathologically characterized as infiltration of inflammatory cells into the terminal bronchioles and surrounding alveoli, pulmonary congestion and bleeding and/or edema. In the subacute study, we observed lymphoid hyperplasia in the perivascular and peribronchial areas, and infiltration of macrophage and plasma cells into the alveoli. In the mice exposed for 4 weeks, the lesions were more severe than in those exposed for 2 weeks, consisting of hyperplasia and desquamation of Clara cells. In the nasal cavity, we saw mucous exudate and inflammatory cells, suggesting irritation caused by diborane. The histopathological findings, except for the respiratory organs, did not reveal any exposure-related changes. No significant changes were seen in hematological and serum biochemical examinations either. In conclusion, the target organ of diborane inhalation is the respiratory organs, particularly the lung. Further inhalation experiments are essential to investigate the safety exposure levels of diborane.

KW - Diborane

KW - Inhalation

KW - Mice

KW - Toxicity

UR - http://www.scopus.com/inward/record.url?scp=0029016690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029016690&partnerID=8YFLogxK

U2 - 10.1007/s002040050190

DO - 10.1007/s002040050190

M3 - Article

C2 - 7495378

AN - SCOPUS:0029016690

VL - 69

SP - 397

EP - 404

JO - Archiv fur Toxikologie

JF - Archiv fur Toxikologie

SN - 0003-9446

IS - 6

ER -