Acute and subacute inhalation toxicity of diborane in male ICR mice

Takamoto Uemura, Kazuyuki Omae, Hiroshi Nakashima, Haruhiko Sakurai, Kazuto Yamazaki, Toshikatsu Shibata, Koji Mori, Mitsuhiro Kudo, Hirokazu Kanoh, Masatomo Tati

研究成果: Article

9 引用 (Scopus)

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To clarify the toxicity of diborane, we conducted acute (15 ppm for 1, 2, 4 or 8h) and subacute (5 ppm for 2 or 4 weeks) inhalation studies on ICR mice. The concentration resulting in a 50% kill after 4 h exposure was 31.5 ppm. body weight gain was suppressed and the lung weight was increased in diborane-exposed mice in both acute and subacute studies. In the acute study, diffuse pan bronchiolitis-like lesions developed in the lung in various degrees depending on exposure time, which can be pathologically characterized as infiltration of inflammatory cells into the terminal bronchioles and surrounding alveoli, pulmonary congestion and bleeding and/or edema. In the subacute study, we observed lymphoid hyperplasia in the perivascular and peribronchial areas, and infiltration of macrophage and plasma cells into the alveoli. In the mice exposed for 4 weeks, the lesions were more severe than in those exposed for 2 weeks, consisting of hyperplasia and desquamation of Clara cells. In the nasal cavity, we saw mucous exudate and inflammatory cells, suggesting irritation caused by diborane. The histopathological findings, except for the respiratory organs, did not reveal any exposure-related changes. No significant changes were seen in hematological and serum biochemical examinations either. In conclusion, the target organ of diborane inhalation is the respiratory organs, particularly the lung. Further inhalation experiments are essential to investigate the safety exposure levels of diborane.

元の言語English
ページ(範囲)397-404
ページ数8
ジャーナルArchives of Toxicology
69
発行部数6
DOI
出版物ステータスPublished - 1995 5 1

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ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

これを引用

Uemura, T., Omae, K., Nakashima, H., Sakurai, H., Yamazaki, K., Shibata, T., Mori, K., Kudo, M., Kanoh, H., & Tati, M. (1995). Acute and subacute inhalation toxicity of diborane in male ICR mice. Archives of Toxicology, 69(6), 397-404. https://doi.org/10.1007/s002040050190