Acute interstitial nephritis associated with ulcerative colitis

Hirobumi Tokuyama, Shu Wakino, Konosuke Konishi, Akinori Hashiguchi, Koichi Hayashi, Hiroshi Itoh

研究成果: Article

10 引用 (Scopus)

抄録

Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.

元の言語English
ページ(範囲)483-486
ページ数4
ジャーナルClinical and Experimental Nephrology
14
発行部数5
DOI
出版物ステータスPublished - 2010 10

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Interstitial Nephritis
Ulcerative Colitis
Inflammatory Bowel Diseases
Kidney
Wounds and Injuries
Pharmaceutical Preparations
Renal Insufficiency

ASJC Scopus subject areas

  • Nephrology
  • Physiology
  • Physiology (medical)

これを引用

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AU - Tokuyama, Hirobumi

AU - Wakino, Shu

AU - Konishi, Konosuke

AU - Hashiguchi, Akinori

AU - Hayashi, Koichi

AU - Itoh, Hiroshi

PY - 2010/10

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AB - Although drugs used in inflammatory bowel diseases (IBD) cause renal injury, glomerulopathies may also accompany IBD. We report a case with the rare association of ulcerative colitis (UC) and acute progressive interstitial nephritis. Although the kidney is acknowledged as a target organ for injury as a result of drug nephrotoxicity, our findings lend support to the novel recognition that the deranged autoimmune system emerging in UC causes interstitial nephritis as an extraintestinal manifestation. Overt renal failure due to interstitial nephritis has rarely been reported in UC patients. The case presented here therefore provides novel information on UC-associated nephropathy.

KW - Acute interstitial nephritis

KW - CD3-positive T cell

KW - Ulcerative colitis

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