Adenosine induces system A amino acid transport in cultured rat hepatocytes

Hiroaki Kiyokawa, Hiroyuki Fukui, Hiroyuki Mizuguchi, Akiharu Kubo, Norio Kono, Seiichiro Tarui, Hiroshi Wada

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Adenosine caused a 2.5-fold increase in the sodium-dependent uptake of 2-aminoisobutyric acid in rat hepatocytes in primary culture following incubation for 3h. The range of stimulating concentrations of adenosine corresponded to that of cAMP formation. Adenosine increased the Vmax of the transport without altering the Km for 2-aminoisobutyric acid. These effects of adenosine were abolished by actinomycin D. N6-L-Phenylisopropyladenosine also caused twofold increase in the amino acid transport. These findings suggest that adenosine induces System A amino acid transport in a transcription-dependent manner, and that P,-purinergic receptors are mainly involved in this action of the nucleoside.

本文言語English
ページ(範囲)9-11
ページ数3
ジャーナルJournal of biochemistry
110
1
DOI
出版ステータスPublished - 1991 7月
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学

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