Adiponectin inhibits murine pancreatic cancer growth

Motohiko Kato, Kenji Watabe, Masahiko Tsujii, Tohru Funahashi, Iichiro Shimomura, Tetsuo Takehara

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Background: Adiponectin is an adipose tissue-derived secretory hormone whose plasma concentrations are lower in obese individuals. Obesity is a risk factor for the development and growth of pancreatic cancer, and hypoadiponectinemia was suggested to be involved in the growth of Pan02 murine pancreatic cancer cells that were inoculated into the flanks of congenitally obese mice. Aim: The aim of this study was to clarify the role of adiponectin in the growth of pancreatic cancer cells. Methods: We examined the effect of adiponectin on the growth of Pan02 cells using recombinant adiponectin and adiponectin knockout mice. Results: The in vitro treatment of Pan02 cells with adiponectin inhibited cellular proliferation that was accompanied by increased apoptosis and caspase-3 and caspase-7 activities. Transplantation of Pan02 cells into the pancreas of knockout mice resulted in a larger tumor volume with fewer terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) positive cells compared with wild-type mice. Conclusions: The results indicate that adiponectin directly suppresses the proliferation of Pan02 cells.

本文言語English
ページ(範囲)1192-1196
ページ数5
ジャーナルDigestive Diseases and Sciences
59
6
DOI
出版ステータスPublished - 2014 6月
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 消化器病学

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