Adult T-cell leukemia: Future prophylaxis and immunotherapy

Mari Kannagi, Nanae Harashima, Kiyoshi Kurihara, Atae Utsunomiya, Ryuji Tanosaki, Masato Masuda

研究成果: Review article査読

15 被引用数 (Scopus)

抄録

A small population of human T-cell leukemia virus Type I (HTLV-I) carriers develop adult T-cell leukemia after a long incubation period. The results of a series of experiments using animal models suggest that insufficiency of HTLV-I-specific T-cell response induced by vertical HTLV-I infection allows enlargement of the HTLV-I-infected cell reservoir in vivo, a crucial risk factor of adult T-cell leukemia. In this review it is proposed that prophylactic Tax-targeted vaccines for the high-risk group of adult T-cell leukemia, which is characterized by low HTLV-I-specific T-cell response and high proviral load, can reduce the risk. Immunological studies on adult T-cell leukemia patients after hematopoietic stem cell transplantation also suggest that Tax-targeted immunotherapy may be effective against full-blown disease, although its indication may be limited.

本文言語English
ページ(範囲)369-376
ページ数8
ジャーナルExpert Review of Anticancer Therapy
4
3
DOI
出版ステータスPublished - 2004 6
外部発表はい

ASJC Scopus subject areas

  • 腫瘍学
  • 薬理学(医学)

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