Age-dependence and chemosensitivity of the pontine inhibitory effect on medullary respiratory rhythm generation were examined in the isolated brainstem-spinal cord of the neonatal rat. In early preparations (days 1-2), the increase in RR (ΔRR) induced by the pons resection was larger in 8% CO2 (pH 7.2) than in 2% CO2 (pH 7.8). That difference was not found in late preparations (days 3-4). Under a given pH, the ΔRR was larger in early preparations than in late preparations.
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