Age influences post-graft-versus-host disease non-relapse mortality in adults with acute graft-versus-host disease of varying severity following allogeneic hematopoietic cell transplant

Takahiko Nakane, Takahiro Fukuda, Junya Kanda, Shuichi Taniguchi, Tetsuya Eto, Kazuteru Ohashi, Hirohisa Nakamae, Mineo Kurokawa, Takehiko Mori, Yasuo Morishima, Tokiko Nagamura-Inoue, Hisashi Sakamaki, Yoshiko Atsuta, Makoto Murata

研究成果: Article査読

2 被引用数 (Scopus)

抄録

We retrospectively analyzed 2682 patients who developed grade II-IV acute graft-versus-host disease (GVHD). On analysis with stratification into five age groups (20-29, 30-39, 40-49, 50-59 and ≥ 60), 2-year non-relapse mortality rates (NRM) after the onset of GVHD were 20.7, 26.2, 26.6, 37.0 and 40.4%, respectively (p < 0.001). We found a significant interaction between the patient's age and GVHD severity with respect to NRM (p = 0.004). On multivariate analyses stratified by GVHD severity, the hazard ratio (HR) for NRM in the groups aged 50 years or more (reference: age group 20-29) was about twice as great in patients with grade II acute GVHD when compared with grade III-IV disease (HR in those aged 50-59 years: 2.9 for grade II and 1.5 [p = 0.03 and 0.04] for grades III-IV; HR if ≥ 60 years: 3.3 for grade II and 1.5 for grades III-IV [p < 0.001 for both]).

本文言語English
ページ(範囲)2392-2397
ページ数6
ジャーナルLeukemia and Lymphoma
56
8
DOI
出版ステータスPublished - 2015 8 3

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

フィンガープリント 「Age influences post-graft-versus-host disease non-relapse mortality in adults with acute graft-versus-host disease of varying severity following allogeneic hematopoietic cell transplant」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル