AGEMAP: A gene expression database for aging in mice

Jacob M. Zahn, Suresh Poosala, Art B. Owen, Donald K. Ingram, Ana Lustig, Arnell Carter, Ashani T. Weeraratna, Dennis D. Taub, Myriam Gorospe, Krystyna Mazan-Mamczarz, Edward G. Lakatta, Kenneth R. Boheler, Xiangru Xu, Mark P. Mattson, Geppino Falco, Minoru S.H. Ko, David Schlessinger, Jeffrey Firman, Sarah K. Kummerfeld, William H. WoodAlan B. Zonderman, Stuart K. Kim, Kevin G. Becker

研究成果: Article査読

271 被引用数 (Scopus)

抄録

We present the AGEMAP (Atlas of Gene Expression in Mouse Aging Project) gene expression database, which is a resource that catalogs changes in gene expression as a function of age in mice. The AGEMAP database includes expression changes for 8,932 genes in 16 tissues as a function of age. We found great heterogeneity in the amount of transcriptional changes with age in different tissues. Some tissues displayed large transcriptional differences in old mice, suggesting that these tissues may contribute strongly to organismal decline. Other tissues showed few or no changes in expression with age, indicating strong levels of homeostasis throughout life. Based on the pattern of agerelated transcriptional changes, we found that tissues could be classified into one of three aging processes: (1) a pattern common to neural tissues, (2) a pattern for vascular tissues, and (3) a pattern for steroid-responsive tissues. We observed that different tissues age in a coordinated fashion in individual mice, such that certain mice exhibit rapid aging, whereas others exhibit slow aging for multiple tissues. Finally, we compared the transcriptional profiles for aging in mice to those from humans, flies, and worms. We found that genes involved in the electron transport chain show common age regulation in all four species, indicating that these genes may be exceptionally good markers of aging. However, we saw no overall correlation of age regulation between mice and humans, suggesting that aging processes in mice and humans may be fundamentally different.

本文言語English
ページ(範囲)2326-2337
ページ数12
ジャーナルPLoS Genetics
3
11
DOI
出版ステータスPublished - 2007 11
外部発表はい

ASJC Scopus subject areas

  • 生態、進化、行動および分類学
  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)
  • 癌研究

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