Aging adversely affects postinfarction inflammatory response and early left ventricular remodeling after reperfused acute anterior myocardial infarction

Keitaro Mahara, Toshihisa Anzai, Tsutomu Yoshikawa, Yuichiro Maekawa, Teruo Okabe, Yasushi Asakura, Toru Satoh, Hideo Mitamura, Masahiro Suzuki, Akira Murayama, Satoshi Ogawa

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Background and Aims: We have demonstrated that an increased peak serum C-reactive protein (CRP) level after acute myocardial infarction (AMI) was a major predictor of left ventricular (LV) remodeling. We sought to clarify the effect of aging on the postinfarction inflammatory response and LV remodeling. Methods: We studied 102 patients who underwent primary angioplasty for a first anterior Q-wave AMI. Serum CRP levels, plasma neuro-hormones and interleukin-6 (IL-6) levels, and LV volume by left ventriculography were serially measured. Patients were divided into two groups according to their age (≥ 70 years, n = 33; <70 years, n = 69). Results: There was no difference in use of cardiovascular drugs and coronary angiographic findings. Older patients had a greater increase in LV end-diastolic volume during 2 weeks after AMI (p = 0.0007) and a higher peak CRP level (12.4 ± 7.3 vs.5.5 ± 4.2 mg/dl, p<0.0001), although peak CK level was comparable between the two groups. Plasma atrial natriuretic peptide, brain natriuretic peptide and IL-6 levels were higher in older patients at 2 weeks and 6 months after AMI. Conclusions: Augmented and prolonged activation of the inflammatory system after AMI was observed in older patients, in association with exaggerated LV remodeling. Aging may adversely affect LV remodeling through modification of the inflammatory response after AMI.

本文言語English
ページ(範囲)67-74
ページ数8
ジャーナルCardiology
105
2
DOI
出版ステータスPublished - 2006 2月

ASJC Scopus subject areas

  • 循環器および心血管医学
  • 薬理学(医学)

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