Aging of the hematopoietic stem cells niche

Ayako Nakamura-Ishizu, Toshio Suda

研究成果: Review article査読

17 被引用数 (Scopus)

抄録

Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

本文言語English
ページ(範囲)317-325
ページ数9
ジャーナルInternational journal of hematology
100
4
DOI
出版ステータスPublished - 2014 10 9

ASJC Scopus subject areas

  • Hematology

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