Air-pressure-driven separable microdevice to control the anisotropic curvature of cell culture surface

Tadahiro Yamashita, Takuya Nishina, Ichiro Matsushita, Ryo Sudo

研究成果: Article査読

抄録

We report on a novel microdevice to tune the curvature of a cell-adhering surface by controlling the air-pressure and micro-slit. Human aortic smooth muscle cells were cultured on demi-cylindrical concaves formed on a microdevice. Their shape-adapting behavior could be tracked when the groove direction was changed to the orthogonal direction. This microdevice demonstrated live observation of cells responding to dynamic changes of the anisotropic curvature of the adhering surface and could serve as a new platform to pursue mechanobiology on curved surfaces.

本文言語English
ページ(範囲)1015-1019
ページ数5
ジャーナルanalytical sciences
36
8
DOI
出版ステータスPublished - 2020

ASJC Scopus subject areas

  • Analytical Chemistry

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