@article{2c86477075ad46ad92e7974e2d7c5cea,
title = "Air-pressure-driven separable microdevice to control the anisotropic curvature of cell culture surface",
abstract = "We report on a novel microdevice to tune the curvature of a cell-adhering surface by controlling the air-pressure and micro-slit. Human aortic smooth muscle cells were cultured on demi-cylindrical concaves formed on a microdevice. Their shape-adapting behavior could be tracked when the groove direction was changed to the orthogonal direction. This microdevice demonstrated live observation of cells responding to dynamic changes of the anisotropic curvature of the adhering surface and could serve as a new platform to pursue mechanobiology on curved surfaces.",
keywords = "Cell adhesion, Curvature, Mechanobiology, Orientation, Smooth muscle cell",
author = "Tadahiro Yamashita and Takuya Nishina and Ichiro Matsushita and Ryo Sudo",
note = "Funding Information: This study was supported by KAKENHI (Grant Numbers 18H05963 and 19K20679) and bilateral programs from Japan Society for the Promotion of Science, Keio Gijuku Academic Development Funds and Keio Leading-edge Laboratory grant. We would like to thank Prof. Kenjiro Takemura (Keio University) and Dr. Chikahiro Imashiro (now Tokyo Women{\textquoteright}s Medical University) for their kind support with machining.",
year = "2020",
doi = "10.2116/analsci.20A001",
language = "English",
volume = "36",
pages = "1015--1019",
journal = "Analytical Sciences",
issn = "0910-6340",
publisher = "Japan Society for Analytical Chemistry",
number = "8",
}