Airflow limitation and airway dimensions in chronic obstructive pulmonary disease

Masaru Hasegawa, Yasuyuki Nasuhara, Yuya Onodera, Hironi Makita, Katsura Nagai, Satoshi Fuke, Yoko Ito, Tomoko Betsuyaku, Masaharu Nishimura

研究成果: Article査読

337 被引用数 (Scopus)

抄録

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation caused by emphysema and/or airway narrowing. Computed tomography has been widely used to assess emphysema severity, but less attention has been paid to the assessment of airway disease using computed tomography. Objectives: To obtain longitudinal images and accurately analyze short axis images of airways with an inner diameter ≥ 2 mm located anywhere in the lung with new software for measuring airway dimensions using curved multiplanar reconstruction. Methods: In 52 patients with clinically stable COPD (stage I, 14; stage II, 22; stage III, 14; stage IV, 2), we used the software to analyze the relationship of the airflow limitation index (FEV1, % predicted) with the airway dimensions from the third to the sixth generations of the apical bronchus (B1) of the right upper lobe and the anterior basal bronchus (B8) of the right lower lobe. Measurements and Main Results: Airway luminal area (Ai) and wall area percent (WA%) were significantly correlated with FEV1 (% predicted). More importantly, the correlation coefficients (r) improved as the airways became smaller in size from the third (segmental) to sixth generations in both bronchi (Ai: r = 0.26, 0.37, 0.58, and 0.64 for B1; r = 0.60, 0.65, 0.63, and 0.73 for B8). Conclusions: We are the first to use three-dimensional computed tomography to demonstrate that airflow limitation in COPD ismore closely related to the dimensions of the distal (small) airways than proximal (large) airways.

本文言語English
ページ(範囲)1309-1315
ページ数7
ジャーナルAmerican journal of respiratory and critical care medicine
173
12
DOI
出版ステータスPublished - 2006 6月 15
外部発表はい

ASJC Scopus subject areas

  • 呼吸器内科
  • 集中医療医学

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