Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis

T. Sugai, K. Fuhshuku

研究成果: Chapter


Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.

ホスト出版物のタイトルComprehensive Organic Synthesis
ホスト出版物のサブタイトルSecond Edition
出版者Elsevier Ltd
出版物ステータスPublished - 2014 2 1

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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  • これを引用

    Sugai, T., & Fuhshuku, K. (2014). Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. : Comprehensive Organic Synthesis: Second Edition (巻 2, pp. 512-522). Elsevier Ltd.