Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis

T. Sugai, K. Fuhshuku

研究成果: Chapter

抄録

Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.

本文言語English
ホスト出版物のタイトルAdditions to C-X π-Bonds, Part 2
出版社Elsevier Ltd
ページ512-522
ページ数11
2
ISBN(印刷版)9780080977430
DOI
出版ステータスPublished - 2014 2

ASJC Scopus subject areas

  • 化学工学(全般)
  • 化学 (全般)

フィンガープリント

「Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル