Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis

Takeshi Sugai, K. Fuhshuku

研究成果: Chapter

抄録

Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.

元の言語English
ホスト出版物のタイトルComprehensive Organic Synthesis: Second Edition
出版者Elsevier Ltd.
ページ512-522
ページ数11
2
ISBN(印刷物)9780080977430
DOI
出版物ステータスPublished - 2014 2

Fingerprint

Fructose-Bisphosphate Aldolase
mandelonitrile lyase
Carbohydrates
Enzymes
Dihydroxyacetone
Nucleophiles
Acetaldehyde
Pyruvic Acid
Drug products
Catalysis
Screening
Proteins
Acids
Substrates
Pharmaceutical Preparations
nitroaldol

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

これを引用

Sugai, T., & Fuhshuku, K. (2014). Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. : Comprehensive Organic Synthesis: Second Edition (巻 2, pp. 512-522). Elsevier Ltd.. https://doi.org/10.1016/B978-0-08-097742-3.00212-3

Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. / Sugai, Takeshi; Fuhshuku, K.

Comprehensive Organic Synthesis: Second Edition. 巻 2 Elsevier Ltd., 2014. p. 512-522.

研究成果: Chapter

Sugai, T & Fuhshuku, K 2014, Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. : Comprehensive Organic Synthesis: Second Edition. 巻. 2, Elsevier Ltd., pp. 512-522. https://doi.org/10.1016/B978-0-08-097742-3.00212-3
Sugai T, Fuhshuku K. Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. : Comprehensive Organic Synthesis: Second Edition. 巻 2. Elsevier Ltd. 2014. p. 512-522 https://doi.org/10.1016/B978-0-08-097742-3.00212-3
Sugai, Takeshi ; Fuhshuku, K. / Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis. Comprehensive Organic Synthesis: Second Edition. 巻 2 Elsevier Ltd., 2014. pp. 512-522
@inbook{1de10b71919c41a09ce77938ad773ebc,
title = "Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis",
abstract = "Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.",
keywords = "3-deoxy-d-manno-2-octusolonic acid aldolase, Aldolase BphI, Deoxyribose-5-phosphate aldolase, Fructose-6-phosphate aldolase, Hydroxynitrile lyase, NAL, Sialic acid aldolase",
author = "Takeshi Sugai and K. Fuhshuku",
year = "2014",
month = "2",
doi = "10.1016/B978-0-08-097742-3.00212-3",
language = "English",
isbn = "9780080977430",
volume = "2",
pages = "512--522",
booktitle = "Comprehensive Organic Synthesis: Second Edition",
publisher = "Elsevier Ltd.",

}

TY - CHAP

T1 - Aldolase-Catalyzed C_C Bond Formation of Carbohydrate Synthesis

AU - Sugai, Takeshi

AU - Fuhshuku, K.

PY - 2014/2

Y1 - 2014/2

N2 - Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.

AB - Three types of aldolase-catalyzed reactions which are promising for C. C bond formation, not only for the practical synthesis of carbohydrates but also in active pharmaceutical ingredients manufacturing, were introduced. The authors focused on the use of three nonphosphorylated nucleophiles: pyruvic acid, acetaldehyde, and dihydroxyacetone. Furthermore, nitroaldol reaction catalyzed by hydroxynitrile lyase (HNL) is noted as an example of catalysis caused by the promiscuous ability of enzymes. All of following the aspects involving screening of new enzymes, characterization, substrate specificity study, synthetic application, and protein engineering are very important in developing improved biocatalytic processes.

KW - 3-deoxy-d-manno-2-octusolonic acid aldolase

KW - Aldolase BphI

KW - Deoxyribose-5-phosphate aldolase

KW - Fructose-6-phosphate aldolase

KW - Hydroxynitrile lyase

KW - NAL

KW - Sialic acid aldolase

UR - http://www.scopus.com/inward/record.url?scp=84903502438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903502438&partnerID=8YFLogxK

U2 - 10.1016/B978-0-08-097742-3.00212-3

DO - 10.1016/B978-0-08-097742-3.00212-3

M3 - Chapter

AN - SCOPUS:84903502438

SN - 9780080977430

VL - 2

SP - 512

EP - 522

BT - Comprehensive Organic Synthesis: Second Edition

PB - Elsevier Ltd.

ER -