All systems go: Launching cell simulation fueled by integrated experimental biology data

Masanori Arita, Martin Robert, Masaru Tomita

研究成果: Review article査読

21 被引用数 (Scopus)

抄録

Biological simulation serves to unify the basic elements of systems biology, namely, model selection, experimentation and model refinement. To select biochemical models for simulation, metabolome analysis can be performed using capillary electrophoresis or liquid chromatography coupled with mass spectrometry. In this manner, selected models can be elaborated with temporal/spatial gene and protein expression data obtained from model organisms such as Escherichia coli. The E. coli single gene deletion mutant library (KO collection) and His-tag/GFP-fusion single open reading frame clone expression library (ASKA) are powerful resources for this task. The integration of parallel experimental datasets into dynamic simulation tools forms the remaining challenge for the systematic analysis and elucidation of biological networks and holds promise for biotechnological applications.

本文言語English
ページ(範囲)344-349
ページ数6
ジャーナルCurrent Opinion in Biotechnology
16
3 SPEC. ISS.
DOI
出版ステータスPublished - 2005 6

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 生体医工学

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