Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma

Masahiro Kami, Tamae Hamaki, Shigesaburo Miyakoshi, Naoko Murashige, Yoshinobu Kanda, Ryuji Tanosaki, Yoichi Takaue, Shuichi Taniguchi, Hisamaru Hirai, Keiya Ozawa, Masaharu Kasai

研究成果: Article査読

80 被引用数 (Scopus)

抄録

The feasibility of allogeneic haematopoietic stem-cell transplantation (allo-HSCT) in 11 patients with adult T-cell leukaemia/lymphoma (ATL) (6 acute, 4 lymphoma, 1 chronic type) was evaluated. The preparative regimens (9 conventional, 2 reduced-intensity) were tolerable. Five patients developed acute graft-versus-host disease (GVHD), and three, extensive chronic GVHD. All 10 patients who survived > 30 d achieved complete remission. Estimated 1-year overall and disease-free survival rates were 53 ± 30% and 45 ± 29% respectively. Four patients remain alive and disease-free at a median follow-up of 25 months. The others died of transplantation-related complications. This pilot study suggests that allo-HSCT in ATL should be evaluated further.

本文言語English
ページ(範囲)304-309
ページ数6
ジャーナルBritish Journal of Haematology
120
2
DOI
出版ステータスPublished - 2003 1月
外部発表はい

ASJC Scopus subject areas

  • 血液学

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