Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: Comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission

Satoshi Nishiwaki, Yoshihiro Inamoto, Hisashi Sakamaki, Mineo Kurokawa, Hiroatsu Iida, Hiroyasu Ogawa, Takahiro Fukuda, Yukiyasu Ozawa, Naoki Kobayashi, Masanobu Kasai, Takehiko Mori, Koji Iwato, Takashi Yoshida, Makoto Onizuka, Keisei Kawa, Yasuo Morishima, Ritsuro Suzuki, Yoshiko Atsuta, Koichi Miyamura

研究成果: Article査読

36 被引用数 (Scopus)

抄録

To identify factors to improve the outcomes of related and unrelated allogeneic stem cell transplantations (allo-SCT) for Philadelphia chromosome-negative acute lymphocytic leukemia (Ph- ALL) in the first complete remission (CR1), we retrospectively analyzed 1139 Ph- ALL patients using the registry data, particularly the details of 641 patients transplanted in CR1. Overall survival was significantly superior among patients transplanted in CR1, but no significant difference was observed between related and unrelated allo-SCTs (related vs unrelated: 65% vs 62% at 4 years, respectively; P = .19). Among patients transplanted in CR1, relapse rates were significantly higher in related allo-SCT compared with unrelated allo-SCT, and multivariate analysis demonstrated that less than 6 months from diagnosis to allo-SCT alone was associated with relapse. On the other hand, nonrelapse mortality (NRM) was significantly higher in unrelated allo-SCT compared with related allo-SCT, and multivariate analysis demonstrated that 10 months or longer from diagnosis to allo-SCT, human leukocyte antigen mismatch, and abnormal karyotype were associated with NRM. In conclusion, our study showed comparable survival rates but different relapse rates, NRM rates, and risk factors between related and unrelated allo-SCTs. After a close consideration of these factors, the outcome of allo-SCT for adult Ph- ALL in CR1 could be improved.

本文言語English
ページ(範囲)4368-4375
ページ数8
ジャーナルBlood
116
20
DOI
出版ステータスPublished - 2010 11 18
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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