Alteration of acidic lipids in human sera during the course of pregnancy: Characteristic increase in the concentration of cholesterol sulfate

Bei Lin, Kaneyuki Kubushiro, Yasuo Akiba, Yongxi Cui, Katsumi Tsukazaki, Shiro Nozawa, Masao Iwamori

研究成果: Article査読

15 被引用数 (Scopus)

抄録

In this study, we determined the concentrations of acidic lipids, including cholesterol sulfate (CS), sulfatide and GM3 ganglioside, in human sera of non-pregnant state and during the course of pregnancy. In human sera of non-pregnant women, GM3 was present at a concentration of 8 nmol/ml and the concentrations of CS and sulfatides were less than 20% of that of GM3. The concentration of sulfatides in sera at the second trimester of gestation was decreased, but CS gradually increased from the first to the third trimester of gestation with a correlation coefficient of 0.66, and a correlation between the concentration of CS and weeks of gestation (p < 0.01). CS was also contained in the placental villi, and its concentration increased from the first to the third trimester of gestation, suggesting that placental CS is one of the source of CS in the blood by shedding.

本文言語English
ページ(範囲)99-104
ページ数6
ジャーナルJournal of Chromatography B: Biomedical Applications
704
1-2
DOI
出版ステータスPublished - 1997 12月 19

ASJC Scopus subject areas

  • 化学 (全般)

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