@article{14f7d52bfcc448219dda20eb0ae29b5c,
title = "Amino acid-based diet prevents lethal infectious diarrhea by maintaining body water balance in a murine citrobacter rodentium infection model",
abstract = "Infectious diarrhea is one of the most important health problems worldwide. Although nutritional status influences the clinical manifestation of various enteric pathogen infections, the effect of diet on enteric infectious diseases remains unclear. Using a fatal infectious diarrheal model, we found that an amino acid-based diet (AD) protected susceptible mice infected with the enteric pathogen Citrobacter rodentium. While the mice fed other diets, including a regular diet, were highly susceptible to C. rodentium infection, AD-fed mice had an increased survival rate. An AD did not suppress C. rodentium colonization or intestinal damage; instead, it prevented diarrhea-induced dehydration by increasing water intake. An AD altered the plasma and fecal amino acid levels and changed the gut microbiota composition. Treatment with glutamate, whose level was increased in the plasma and feces of AD-fed mice, promoted water intake and improved the survival of C. ro-dentium-infected mice. Thus, an AD changes the systemic amino acid balance and protects against lethal infectious diarrhea by maintaining total body water content.",
keywords = "Amino acid-based diet, Citrobacter rodentium, Dehydration, Diarrhea, Enteric infection",
author = "Tatsuki Kimizuka and Natsumi Seki and Genki Yamaguchi and Masahiro Akiyama and Seiichiro Higashi and Koji Hase and Kim, {Yun Gi}",
note = "Funding Information: Acknowledgments: We thank our laboratory members for helpful discussions. Graphical abstract was created using www.biorender.io (accessed on 27 May 2021) Conflicts of Interest: Seiichiro Higashi is an employee of Co-Creation Center, Meiji Holdings Co., Ltd.,Tokyo, Japan. This study was funded by Meiji Holdings Co. Funding Information: This work was supported by research grants from JSPS KAKENHI (JP17H05068 and JP20H03490 to Y.-G.K.), AMED (JP18gm6010004h0003 to Y.-G.K.), and Yakult BioScience Foundation (to Y.-G.K.). We thank our laboratory members for helpful discussions. Funding Information: Funding: This work was supported by research grants from JSPS KAKENHI (JP17H05068 and JP20H03490 to Y.-G.K.), AMED (JP18gm6010004h0003 to Y.-G.K.), and Yakult Bio-Science Foundation (to Y.-G.K.). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = jun,
doi = "10.3390/nu13061896",
language = "English",
volume = "13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "6",
}