Amplitude and frequency feature extraction of neural activity in mouse ventrolateral striatum under different motivational states using fiber photometric system

S. Imai, Y. Mitsukura, K. Yoshida, I. Tsutsui-Kimura, N. Takata, K. F. Tanaka

研究成果: Conference contribution

抄録

In this paper, we focused on the motivation of mice and aimed to extract neural activity features of D2 medium spiny neurons (D2-MSNs) in the ventrolateral striatum of mice under different motivational states. Motivated behavior is defined as the activation of goal-directed behavior, and this enables actions such as ingestion, sleeping and reproduction, which are essential for living. In human society, motivation allows us to participate in society, improving our quality of life. Loss of motivation has been causing problems such as withdrawal from society. If the symptom is heavy, it can even threaten our lives, and treatment is necessary. The mechanisms which lead to loss of motivation are yet to be understood, and an effective treatment does not exist. To solve these problems, we decided to find features in the neural activity which affect motivation, because understanding the mechanism may contribute to the establishment of treatment. In the experiment, the neural activity was recorded using gene-encoded ratio metric calcium ion (Ca2+) indicator and by constructing a fiber photometric system, which enabled recording of neural activity at specific brain region for specific type of neurons. While the recording took place, mice performed food-incentive leverpressing tasks, which were used to define motivational states. The experimental results show that both the amplitude and frequency components of Ca2+ fluctuation have features which are good predictors of motivational states.

本文言語English
ホスト出版物のタイトル2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings
出版社Institute of Electrical and Electronics Engineers Inc.
ページ1-6
ページ数6
ISBN(電子版)9781538648735
DOI
出版ステータスPublished - 2017 7 1
イベント2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Philadelphia, United States
継続期間: 2017 12 2 → …

出版物シリーズ

名前2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017 - Proceedings
2018-January

Other

Other2017 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2017
国/地域United States
CityPhiladelphia
Period17/12/2 → …

ASJC Scopus subject areas

  • 信号処理
  • 循環器および心血管医学
  • 健康情報学
  • 臨床神経学

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