An 8-year-old boy with anti-NMDA receptor encephalitis, successfully treated with cyclophosphamide

Tadahiro Mitani, Yoshimitsu Ohtsuka, Kei Yamamoto, Yoshihiro Watanabe, Megumi Tsuji, Kiyoko Samejima, Noriko Aida, Takeshi Sato, Takahito Wada, Hitoshi Osaka

研究成果: Article査読

抄録

We report on an 8-year-old boy with non-paraneoplastic anti-NMDA receptor (NMDAR) encephalitis, who presented with psychotic symptoms and involuntary movement following an intractable seizure. His serum and CSF tested positive for anti-NMDAR antibodies. He received an initial immunotherapy consisting of methylprednisolone pulse therapy (mPSL) and intravenous immunoglobulin therapy (IVIg), without any clinical improvement. He had three cycles of monthly cyclophosphamide pulse therapy (500 mg/m2), and his clinical condition started to improve gradually two weeks after the first cycle, without any side effects. Six months after onset, he tested normal upon standard neurological examination. Cyclophosphamide therapy should be considered for children with anti-NMDAR encephalitis, as well as mPSL and IVIg.

本文言語English
ページ(範囲)53-57
ページ数5
ジャーナルNO TO HATTATSU
45
1
出版ステータスPublished - 2013 1月
外部発表はい

ASJC Scopus subject areas

  • 小児科学、周産期医学および子どもの健康
  • 臨床神経学

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