An access to the 13-membered cyclophane substructure in GKK1032AS: An intramolecular 1,4-addition approach

Satoka Nagai, Yuka Yamagishi, Yuta Shimizu, Ken Ichi Takao, Kin Ichi Tadano

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The construction of the 13-membered para-cyclophane substructure in GKK1032As, a member of novel pyrrolidinone-containing bioactive natural products, has been explored. An efficient approach for this synthetically formidable object was found, which relied on an intramolecular 1,4-addition between a nitromethylene group and a vinyl ketone moiety both incorporated as side chains into the 6/5/6-tricyclic (the A/B/C-ring system) of the GKK1032s.

本文言語English
ページ(範囲)819-826
ページ数8
ジャーナルHeterocycles
90
2
DOI
出版ステータスPublished - 2015

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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