An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora

M. Tomoda, K. Matsumoto, N. Shimizu, R. Gonda, N. Ohara, K. Hirabayashi

研究成果: Article

16 引用 (Scopus)

抄録

An acidic polysaccharide, called peonan PA, was isolated from the root of Paeonia lactiflora Pallas. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 6.0 x 104. Peonan PA is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 2:1:10, in addition to small amounts of O-acetyl groups and peptide moieties. About forty percent of the hexuronic acid residues in peonan PA exist as methyl esters. Reduction of carboxyl groups, methylation analysis, lithium degradation and nuclear magnetic resonance studies indicated that its main structural features involve both α-1,5-linked L-arabino-β-3,6-branched D-galactan type and α-1,4-linked D-galacturonan type structural units. The polysaccharide exhibited remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and considerable anti-complementary activity.

元の言語English
ページ(範囲)1161-1164
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
17
発行部数9
出版物ステータスPublished - 1994
外部発表Yes

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Paeonia
Polysaccharides
Hexuronic Acids
Mononuclear Phagocyte System
Arabinose
Galactose
Lithium
Methylation
Gel Chromatography
Electrophoresis
Esters
Magnetic Resonance Spectroscopy
Carbon
Peptides
peonan PA

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

これを引用

Tomoda, M., Matsumoto, K., Shimizu, N., Gonda, R., Ohara, N., & Hirabayashi, K. (1994). An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora. Biological and Pharmaceutical Bulletin, 17(9), 1161-1164.

An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora. / Tomoda, M.; Matsumoto, K.; Shimizu, N.; Gonda, R.; Ohara, N.; Hirabayashi, K.

:: Biological and Pharmaceutical Bulletin, 巻 17, 番号 9, 1994, p. 1161-1164.

研究成果: Article

Tomoda, M, Matsumoto, K, Shimizu, N, Gonda, R, Ohara, N & Hirabayashi, K 1994, 'An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora', Biological and Pharmaceutical Bulletin, 巻. 17, 番号 9, pp. 1161-1164.
Tomoda, M. ; Matsumoto, K. ; Shimizu, N. ; Gonda, R. ; Ohara, N. ; Hirabayashi, K. / An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora. :: Biological and Pharmaceutical Bulletin. 1994 ; 巻 17, 番号 9. pp. 1161-1164.
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AU - Shimizu, N.

AU - Gonda, R.

AU - Ohara, N.

AU - Hirabayashi, K.

PY - 1994

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N2 - An acidic polysaccharide, called peonan PA, was isolated from the root of Paeonia lactiflora Pallas. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 6.0 x 104. Peonan PA is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 2:1:10, in addition to small amounts of O-acetyl groups and peptide moieties. About forty percent of the hexuronic acid residues in peonan PA exist as methyl esters. Reduction of carboxyl groups, methylation analysis, lithium degradation and nuclear magnetic resonance studies indicated that its main structural features involve both α-1,5-linked L-arabino-β-3,6-branched D-galactan type and α-1,4-linked D-galacturonan type structural units. The polysaccharide exhibited remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and considerable anti-complementary activity.

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