An air-driven microdevice to tune the anisotropic curvature of cell adhesion plane to pursue the mechanobiology of curved surface

Tadahiro Yamashita, Ichiro Matsushita, Ryo Sudo

研究成果: Conference contribution

抄録

A new microdevice controlling the curvature of cell adhering plane is proposed. This microdevice is composed of a cell culture chamber with thin silicone membrane, a microslit and a vacuum chamber. Controlling the air pressure, the curvature of the cell adhering plane can be flexibly tuned in a spatiotemporal way. To prove the concept, vascular smooth muscle is cultured on the curved surface and their response to sudden curvature change is monitored. This microdevice would contribute to pursue fundamental question on how cells recognize the surrounding geometry, which is one of the core interests in the mechanobiology field.

本文言語English
ホスト出版物のタイトル23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
出版社Chemical and Biological Microsystems Society
ページ320-321
ページ数2
ISBN(電子版)9781733419000
出版ステータスPublished - 2019
イベント23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
継続期間: 2019 10 272019 10 31

出版物シリーズ

名前23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
国/地域Switzerland
CityBasel
Period19/10/2719/10/31

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 化学工学(その他)

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