An algorithm to evaluate the number of trabecular cell layers using nucleus arrangement applied to hepatocellular carcinoma

Hideki Komagata, Naoki Kobayashi, Ayako Katoh, Yasuka Ohnuki, Masahiro Ishikawa, Kazuma Shinoda, Masahiro Yamaguchi, Tokiya Abe, Akinori Hashiguchi, Michiie Sakamoto

研究成果: Conference contribution

2 被引用数 (Scopus)

抄録

Recent advances in information technology have improved pathological virtual-slide technology and diagnostic support system studies of pathological images. Diagnostic support systems utilize quantitative indices determined by image processing. In previous studies on diagnostic support systems, carcinomatous areas of breast or lung have been recognized by the feature quantities of nuclear sizes, complexities, and internuclear distances based on graph theory, among other features. Improving recognition accuracy is important for the addition of new feature quantities. We focused on hepatocellular carcinoma (HCC) and investigated new feature quantities of histological images of HCC. One of the most important histological features of HCC is the trabecular pattern. For diagnosing cancer, it is important to recognize the tumor cell trabeculae. We propose a new algorithm for calculating the number of cell layers in histological images of HCC in tissue sections stained by hematoxylin and eosin. For the calculation, we used a Delaunay diagram that was based on the median points of nuclei, deleted the sinusoid and fat droplet regions from the Delaunay diagram, and counted the Delaunay lines while applying a thinning algorithm. Moreover, we experimented with the calculation of the number of cell layers with our method for different histological grades of HCC. The number of cell layers discriminated tumor differentiations and Edmondson grades; therefore, our algorithm may serve as an index of HCC for diagnostic support systems.

本文言語English
ホスト出版物のタイトルMedical Imaging 2013
ホスト出版物のサブタイトルDigital Pathology
DOI
出版ステータスPublished - 2013 6 10
イベントSPIE Medical Imaging Symposium 2013: Digital Pathology - Lake Buena Vista, FL, United States
継続期間: 2013 2 102013 2 11

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
8676
ISSN(印刷版)1605-7422

Other

OtherSPIE Medical Imaging Symposium 2013: Digital Pathology
CountryUnited States
CityLake Buena Vista, FL
Period13/2/1013/2/11

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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