An alternative synthesis of 1,1′-Bis-valienamine from d -glucose

Tony K.M. Shing, Hau M. Cheng

研究成果: Article査読

9 被引用数 (Scopus)

抄録

An alternative synthesis of 1,1′-bis-valienamine 5, which was demonstrated to be a potent trehalase inhibitor, has been achieved from d-glucose in 12 steps with 15% overall yield via enone 12 as the key intermediate, involving a direct aldol reaction of a glucose-derived diketone and a palladium-catalyzed allylic coupling reaction as the key steps.

本文言語English
ページ(範囲)3522-3525
ページ数4
ジャーナルJournal of Organic Chemistry
75
10
DOI
出版ステータスPublished - 2010 5 21

ASJC Scopus subject areas

  • 有機化学

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