An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: Effects of *09:01 allele on disease phenotypes

Kenichi Shimane, Yuta Kochi, Akari Suzuki, Yukinori Okada, Tomonori Ishii, Tetsuya Horita, Kazuyoshi Saito, Akiko Okamoto, Norihiro Nishimoto, Keiko Myouzen, Michiaki Kubo, Michito Hirakata, Takayuki Sumida, Yoshinari Takasaki, Ryo Yamada, Yusuke Nakamura, Naoyuki Kamatani, Kazuhiko Yamamoto

研究成果: Article

35 引用 (Scopus)

抜粋

Objective: To re-evaluate the roles of HLA-DRB1 alleles in susceptibility to SLE and RA and their effects on autoantibody status in large-scale Japanese cohorts. Methods: A total of 656 SLE, 2410 RA and 911 control subjects, who were all Japanese, were genotyped for HLA-DRB1 alleles using sequence-specific oligonucleotide probes. The association of alleles with disease susceptibility was tested by logistic regression analysis and by the relative predispositional effect method. The association with autoantibody status was examined by the standard -2 test. Results: HLA-DRB1*15:01, *09:01, *08:02 and *04:01 were significantly associated with SLE susceptibility, while shared epitope (SE) alleles and DRB1*09:01 were associated with RA susceptibility. The compound heterozygote of DRB1*09:01/*15:01 conferred an increased risk for SLE compared with the homozygotes for DRB1*09:01 and *15:01 and was associated with earlier onset of disease, whereas the compound effect of DRB1-SE/*09:01 was not clear in RA. DRB1*09:01 was significantly associated with the appearance of anti-Sm antibody in SLE as well as ACPA in RA, while protectively associated with anti-dsDNA antibody in SLE. No significant interaction was observed between DRB1*09:01 and smoking status for the appearance of ACPA, unlike that observed in SE alleles in RA. Conclusion: We identified HLA-DRB1 alleles associated with SLE and RA in a Japanese population and demonstrated a shared susceptibility of DRB1*09:01 between the diseases as well as its effect on autoantibody production.

元の言語English
ページ(範囲)1172-1182
ページ数11
ジャーナルRheumatology (United Kingdom)
52
発行部数7
DOI
出版物ステータスPublished - 2013 7

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

フィンガープリント An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: Effects of *09:01 allele on disease phenotypes' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Shimane, K., Kochi, Y., Suzuki, A., Okada, Y., Ishii, T., Horita, T., Saito, K., Okamoto, A., Nishimoto, N., Myouzen, K., Kubo, M., Hirakata, M., Sumida, T., Takasaki, Y., Yamada, R., Nakamura, Y., Kamatani, N., & Yamamoto, K. (2013). An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: Effects of *09:01 allele on disease phenotypes. Rheumatology (United Kingdom), 52(7), 1172-1182. https://doi.org/10.1093/rheumatology/kes427