An autopsy case of Reye syndrome during a remission of malignant lymphoma

Y. Hamano, T. Suda, S. Kamoshita, M. Koike

研究成果: Article

抄録

This paper describes clinical and pathological studies on a patient who acutely died of Reye syndrome during a complete remission of malignant lymphoma. Although Reye syndrome is not a common disease in Japan, the number of case reports has been increasing. Yet such a combination with malignancy as in the present case seems extremely rare. The patient was a 4-year-old boy who developed a left mandibular swelling at 2 years of age, was diagnosed as undifferentiated malignant lymphoma by biopsy, and was treated with vincristine, methotrexate, prednisolone and adriamycin. One month after the completion of chemotherapy, the patient was readmitted to our hospital, because of sudden onset of recurrent vomiting, tachypnea, cyanosis, and consciousness disturbance. Laboratory studies revealed metabolic acidosis and hepatic dysfunction with elevated GOT (341 U), GPT (89 U), CPK (983 U), and blood ammonia (106 μg/dl). Blood sugar was 5 mg/dl. The CPK isozyme pattern was MM 79%, MB 21% and BB 1%. Serum virus titers including influenza B and chikenpox were within normal limits. Lumbar rap revealed a clear CSF with a mild pleocytosis (326/3/mm3). The patient died on the day of admission. Autopsy showed a gross appearance and histological evidence of fatty degeneration of liver and kidneys. Myocardium also showed fatty degeneration. The brain was edematous, and showed a tonsillar herniation of cerebellum. There was no evidence of relapse of malignant lymphoma. The clinical, laboratory, and pathological findings of the present case are consistent with Reye syndrome, although it took an unusually acute course. It is suggested that such an acute course was somehow related with underlying malignant lymphoma or its chemotherapy.

元の言語English
ページ(範囲)438-444
ページ数7
ジャーナルNo To Hattatsu
15
発行部数5
出版物ステータスPublished - 1983

Fingerprint

Reye Syndrome
Autopsy
Lymphoma
Encephalocele
Tachypnea
Drug Therapy
Cyanosis
Leukocytosis
Vincristine
Fatty Liver
Prednisolone
Acidosis
Viral Load
Consciousness
Ammonia
Methotrexate
Non-Hodgkin's Lymphoma
Doxorubicin
Cerebellum
Human Influenza

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health

これを引用

Hamano, Y., Suda, T., Kamoshita, S., & Koike, M. (1983). An autopsy case of Reye syndrome during a remission of malignant lymphoma. No To Hattatsu, 15(5), 438-444.

An autopsy case of Reye syndrome during a remission of malignant lymphoma. / Hamano, Y.; Suda, T.; Kamoshita, S.; Koike, M.

:: No To Hattatsu, 巻 15, 番号 5, 1983, p. 438-444.

研究成果: Article

Hamano, Y, Suda, T, Kamoshita, S & Koike, M 1983, 'An autopsy case of Reye syndrome during a remission of malignant lymphoma', No To Hattatsu, 巻. 15, 番号 5, pp. 438-444.
Hamano Y, Suda T, Kamoshita S, Koike M. An autopsy case of Reye syndrome during a remission of malignant lymphoma. No To Hattatsu. 1983;15(5):438-444.
Hamano, Y. ; Suda, T. ; Kamoshita, S. ; Koike, M. / An autopsy case of Reye syndrome during a remission of malignant lymphoma. :: No To Hattatsu. 1983 ; 巻 15, 番号 5. pp. 438-444.
@article{aba365f740f44aa4b227adc48cafa178,
title = "An autopsy case of Reye syndrome during a remission of malignant lymphoma",
abstract = "This paper describes clinical and pathological studies on a patient who acutely died of Reye syndrome during a complete remission of malignant lymphoma. Although Reye syndrome is not a common disease in Japan, the number of case reports has been increasing. Yet such a combination with malignancy as in the present case seems extremely rare. The patient was a 4-year-old boy who developed a left mandibular swelling at 2 years of age, was diagnosed as undifferentiated malignant lymphoma by biopsy, and was treated with vincristine, methotrexate, prednisolone and adriamycin. One month after the completion of chemotherapy, the patient was readmitted to our hospital, because of sudden onset of recurrent vomiting, tachypnea, cyanosis, and consciousness disturbance. Laboratory studies revealed metabolic acidosis and hepatic dysfunction with elevated GOT (341 U), GPT (89 U), CPK (983 U), and blood ammonia (106 μg/dl). Blood sugar was 5 mg/dl. The CPK isozyme pattern was MM 79{\%}, MB 21{\%} and BB 1{\%}. Serum virus titers including influenza B and chikenpox were within normal limits. Lumbar rap revealed a clear CSF with a mild pleocytosis (326/3/mm3). The patient died on the day of admission. Autopsy showed a gross appearance and histological evidence of fatty degeneration of liver and kidneys. Myocardium also showed fatty degeneration. The brain was edematous, and showed a tonsillar herniation of cerebellum. There was no evidence of relapse of malignant lymphoma. The clinical, laboratory, and pathological findings of the present case are consistent with Reye syndrome, although it took an unusually acute course. It is suggested that such an acute course was somehow related with underlying malignant lymphoma or its chemotherapy.",
author = "Y. Hamano and T. Suda and S. Kamoshita and M. Koike",
year = "1983",
language = "English",
volume = "15",
pages = "438--444",
journal = "No To Hattatsu",
issn = "0029-0831",
publisher = "Japanese Society of Child Neurology",
number = "5",

}

TY - JOUR

T1 - An autopsy case of Reye syndrome during a remission of malignant lymphoma

AU - Hamano, Y.

AU - Suda, T.

AU - Kamoshita, S.

AU - Koike, M.

PY - 1983

Y1 - 1983

N2 - This paper describes clinical and pathological studies on a patient who acutely died of Reye syndrome during a complete remission of malignant lymphoma. Although Reye syndrome is not a common disease in Japan, the number of case reports has been increasing. Yet such a combination with malignancy as in the present case seems extremely rare. The patient was a 4-year-old boy who developed a left mandibular swelling at 2 years of age, was diagnosed as undifferentiated malignant lymphoma by biopsy, and was treated with vincristine, methotrexate, prednisolone and adriamycin. One month after the completion of chemotherapy, the patient was readmitted to our hospital, because of sudden onset of recurrent vomiting, tachypnea, cyanosis, and consciousness disturbance. Laboratory studies revealed metabolic acidosis and hepatic dysfunction with elevated GOT (341 U), GPT (89 U), CPK (983 U), and blood ammonia (106 μg/dl). Blood sugar was 5 mg/dl. The CPK isozyme pattern was MM 79%, MB 21% and BB 1%. Serum virus titers including influenza B and chikenpox were within normal limits. Lumbar rap revealed a clear CSF with a mild pleocytosis (326/3/mm3). The patient died on the day of admission. Autopsy showed a gross appearance and histological evidence of fatty degeneration of liver and kidneys. Myocardium also showed fatty degeneration. The brain was edematous, and showed a tonsillar herniation of cerebellum. There was no evidence of relapse of malignant lymphoma. The clinical, laboratory, and pathological findings of the present case are consistent with Reye syndrome, although it took an unusually acute course. It is suggested that such an acute course was somehow related with underlying malignant lymphoma or its chemotherapy.

AB - This paper describes clinical and pathological studies on a patient who acutely died of Reye syndrome during a complete remission of malignant lymphoma. Although Reye syndrome is not a common disease in Japan, the number of case reports has been increasing. Yet such a combination with malignancy as in the present case seems extremely rare. The patient was a 4-year-old boy who developed a left mandibular swelling at 2 years of age, was diagnosed as undifferentiated malignant lymphoma by biopsy, and was treated with vincristine, methotrexate, prednisolone and adriamycin. One month after the completion of chemotherapy, the patient was readmitted to our hospital, because of sudden onset of recurrent vomiting, tachypnea, cyanosis, and consciousness disturbance. Laboratory studies revealed metabolic acidosis and hepatic dysfunction with elevated GOT (341 U), GPT (89 U), CPK (983 U), and blood ammonia (106 μg/dl). Blood sugar was 5 mg/dl. The CPK isozyme pattern was MM 79%, MB 21% and BB 1%. Serum virus titers including influenza B and chikenpox were within normal limits. Lumbar rap revealed a clear CSF with a mild pleocytosis (326/3/mm3). The patient died on the day of admission. Autopsy showed a gross appearance and histological evidence of fatty degeneration of liver and kidneys. Myocardium also showed fatty degeneration. The brain was edematous, and showed a tonsillar herniation of cerebellum. There was no evidence of relapse of malignant lymphoma. The clinical, laboratory, and pathological findings of the present case are consistent with Reye syndrome, although it took an unusually acute course. It is suggested that such an acute course was somehow related with underlying malignant lymphoma or its chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0020565415&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020565415&partnerID=8YFLogxK

M3 - Article

C2 - 6661330

AN - SCOPUS:0020565415

VL - 15

SP - 438

EP - 444

JO - No To Hattatsu

JF - No To Hattatsu

SN - 0029-0831

IS - 5

ER -