An efficient method for the synthesis of versatile intermediates leading to 13-deoxy- and 9,13-dideoxyphorbols

Akihiro Sekine, Naoya Kumagai, Koichiro Uotsu, Takashi Ohshima, Masakatsu Shibasaki

研究成果: Article査読

13 被引用数 (Scopus)

抄録

An efficient method for the synthesis of versatile intermediates for biologically interesting 13-deoxy- and 9,13-dideoxyphorbol ester analogs is described. First, more efficient synthetic routes to the bicyclic ketones 7 and 8, which are well-known intermediates for the synthesis of 13- deoxyphorbols, than the previous one were established. Second, 7 and 8 were successfully converted to the intermediates 19, 25 and 27 for the synthesis of 9,13-dideoxyphorbols using Peterson reaction, oxymercuration and nitrile oxide cycloaddition as key steps.

本文言語English
ページ(範囲)509-513
ページ数5
ジャーナルTetrahedron Letters
41
4
DOI
出版ステータスPublished - 2000 1月 22
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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