An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain

Steven R. King, Pulak R. Manna, Tomohiro Ishii, Peter J. Syapin, Stephen D. Ginsberg, Kevin Wilson, Lance P. Walsh, Keith L. Parker, Douglas M. Stocco, Roy G. Smith, Dolores J. Lamb

研究成果: Article査読

166 被引用数 (Scopus)

抄録

Recent data implicate locally produced steroids, termed neurosteroids, as regulators of neuronal function. Adrenal and gonadal steroidogenesis is controlled by changes in the steroidogenic acute regulatory protein (StAR); however, little is known about the regulation of neurosteroid production. We now demonstrate unequivocally that StAR mRNA and protein are expressed within glia and neurons in discrete regions of the mouse brain, and that glial StAR expression is inducible. Con sistent with a role in de novo neurosteroidogenesis, StAR colocalizes with the cholesterol side-chain cleavage enzyme P450scc in both mouse and human brains. These data support a role for StAR in the production of neurosteroids and identify potential sites of active de novo steroid synthesis in the brain.

本文言語English
ページ(範囲)10613-10620
ページ数8
ジャーナルJournal of Neuroscience
22
24
DOI
出版ステータスPublished - 2002 12月 15
外部発表はい

ASJC Scopus subject areas

  • 神経科学(全般)

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