An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta

Kazuaki Taguchi, Keishi Yamasaki, Hiroki Maesaki, Masahiro Tokuno, Shoko Okazaki, Hiroshi Moriuchi, Keizo Takeshita, Masaki Otagiri, Hakaru Seo

研究成果: Article査読

7 被引用数 (Scopus)

抄録

Hemerocallis fulva L. var. sempervirens M. Hotta (kwanso) represents an exceptional resource for identifying and developing new phytomedicines for the treatment and prevention of disease. The aim of this study was to conduct a detailed investigation of the biological activities of kwanso. Our study resulted in four major findings. First, kwanso scavenges hydroxyl radicals generated by H2O2/UV light system in vitro in a dose-dependent manner. Second, hepatic glutathione levels were significantly increased when kwanso was orally administered to mice. Third, the oral administration of kwanso to mice showed a tendency to suppress hepatic injury induced by acetaminophen. Finally, kwanso slightly inhibited cytochrome P450 3A activity. These results provide useful evidence in support of the development of kwanso as a candidate raw material for the treatment and prevention of disease.

本文言語English
ページ(範囲)2211-2213
ページ数3
ジャーナルNatural Product Research
28
23
DOI
出版ステータスPublished - 2014 12 5
外部発表はい

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

フィンガープリント 「An evaluation of novel biological activity in a crude extract from Hemerocallis fulva L. var. sempervirens M. Hotta」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル