@article{ac96fe28855b4180baf0f048fecdd480,
title = "An expeditious chemo-enzymatic synthesis of dihydronorcapsaicin β-d-glucopyranoside",
abstract = "A seven-step and scalable synthesis of dihydronorcapsaicin β-d-glucopyranoside, non-pungent and adrenal secretion enhancement activity (diet effect), was accomplished from vanillin. A simple and inexpensive glucosyl donor, acetobromoglucose, was reacted with phenolic hydroxyl group of α-iodovanillin nitrile under basic conditions. Another key step was the lipase-catalyzed coupling reaction of primary amine, which was resulted from the reduction of the glucosylated product, with methyl nonanoate.",
keywords = "Aminolysis, Capsaicin, Glucoside, Lipase, Vanillin",
author = "Israt Sultana and Miwa Shimamoto and Rika Obata and Shigeru Nishiyama and Takeshi Sugai",
note = "Funding Information: This work was accomplished as the 21st Century COE Program (KEIO LCC) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. Part of this work was also supported by Grant-in-Aid for Scientific Research (No. 16580092).",
year = "2006",
month = mar,
doi = "10.1016/j.stam.2005.10.005",
language = "English",
volume = "7",
pages = "197--201",
journal = "Science and Technology of Advanced Materials",
issn = "1468-6996",
publisher = "IOP Publishing Ltd.",
number = "2",
}