An expeditious route to GlcNAc-Cbz-Asn by chemo-enzymatic synthesis

Y. Tokuda, Y. Takahashi, K. Matoishi, Y. Ito, T. Sugai

研究成果: Article査読

4 被引用数 (Scopus)

抄録

A short-step route to GlcNAc-Cbz-Asn was developed. Treatment of GlcNAc in sat. aq. NH4HCO3 solution and subsequent electorodialytic desalting provided ammonia-free glycosylamine in large quantity. The product was coupled with Cbz-Asn α-isobutyl ester β-fluoride, and finally, the isobutyl ester was deprotected by enzyme-catalyzed hydrolysis under mild conditions.

本文言語English
ページ(範囲)57-60
ページ数4
ジャーナルSynlett
1
DOI
出版ステータスPublished - 2002 1 1

ASJC Scopus subject areas

  • 有機化学

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